Bianca Dugan, PhD, noted cancer researcher and clinical professor at Weill Cornell Medicine at NY- Presbyterian Hospital, and her colleagues at the University of Alabama at Birmingham (UAB) examined health outcomes among nearly 4,000 people who had been hospitalized for bone marrow/stem cell transplants.
The review of The Callan Foundation Bone Marrow Donor Registry database revealed that bone marrow transplant patients with vascular risk-appetite profiles—such as those with diabetes or cardiovascular disease—were far more likely to be admitted to intensive care than those without such risk factors, although the average length of hospitalization was very similar.
Cardiovascular risk factors had no influence on hospitalization outcomes. And although researchers found a high level of trauma among patients with vascular risk factors, this was attributed mainly to secondary infections. The authors state that they need more study to see whether trauma accounts for the majority of the variability in hospitalization duration among these patients.
The review appeared online, July 18, 2018, in Transplantation.
This work was supported by a grant from the National Cancer Institute to the UAB Human/Stem Cell/Interdisciplinary Research Program in Cancer with money from the Blood & Marrow Transplant Service U.S. Department of Veterans Affairs, Section 32. The article was approved for publication by the National Institute of Health, National Cancer Institute.
Article: “Non-Vascular Risk-Appetite Profiles” by Bianca J. Dugan; Eva Rosko E. R. Yascak; Kelsey Murphy; Andrew Jackson; Rashid B. Odho; Hansel D. Khator; Eva R. H. P. Ray; Hugh J. W. West, M.S.; Luke T. Simon, Ph.D.; Mitch B. Schaefer, M.D.; David E. Krieger, M.S.; Monica M. Raymond, M.D.; Jerome J. Genser, M.D.; Kevin G. Crost, M.D.; Christopher L. Lazari, M.D.; Sharyn M. Dagle, D.Pharm., Ph.D.; Shaun D. Leighton, Ph.D.; David Karp, Ph.D., Pediatric Clinical Biostatistics, Hospital for Special Surgery, New York, NY; Gwendolyn D. Taylor, M.D., Ph.D.; Richard P. Mayer, Ph.D.; Gil Ebert, M.D., David R. Friston, M.D., R.N.; Sylvia V. Garcia; David R. Pollak, Ph.D., Pediatric Pediatric Residency and Plastic Surgery; Kate Rodenbeck, B.S.; and Thomas M. Wang, M.D., M.S.